Interactions between Trypanosoma cruzi Secreted Proteins and Host Cell Signaling Pathways
نویسندگان
چکیده
منابع مشابه
Interactions between Trypanosoma cruzi Secreted Proteins and Host Cell Signaling Pathways
Chagas disease is one of the prevalent neglected tropical diseases, affecting at least 6-7 million individuals in Latin America. It is caused by the protozoan parasite Trypanosoma cruzi, which is transmitted to vertebrate hosts by blood-sucking insects. After infection, the parasite invades and multiplies in the myocardium, leading to acute myocarditis that kills around 5% of untreated individu...
متن کاملSignaling Pathways in Trypanosoma cruzi that Modulate Host Cell Interaction
Members of the Gp85/trans-sialidase (Gp85/TS) superfamily and mucins play an essential role in the invasion of host cells by T. cruzi trypomastigotes. Together, they constitute a large portion of the genome; approximately 700 and 433 genes encode Gp85/TS glycoproteins and mucins (as do a similar amount of pseudogenes), respectively. Gp85/TS proteins bind to a variety of host cell receptors and ...
متن کاملEnvironment, interactions between Trypanosoma cruzi and its host, and health.
An epidemiological chain involving Trypanosoma cruzi is discussed at the environmental level, and in terms of fine molecular interactions in invertebrate and vertebrate hosts dwelling in different ecosystems. This protozoan has a complex, genetically controlled plasticity, which confers adaptation to approximately 40 blood-sucking triatomine species and to over 1,000 mammalian species, fulfilli...
متن کاملTrypanosoma cruzi–Host Cell Interaction
Chagas disease was discovered by Carlos Chagas in Brazil in 1909 (1). It is caused by the pathogenic protozoan Trypanosoma cruzi, member of Trypanosomatidae family, Kinetoplastida order. Chagas disease is recognized by the World Health Organization as one of the main neglected tropical diseases, affecting about 8–15 million individuals in 18 countries in Central and South America, where it is e...
متن کاملReview on Trypanosoma cruzi: Host Cell Interaction
Trypanosoma cruzi, the causative agent of Chagas' disease, which affects a large number of individuals in Central and South America, is transmitted to vertebrate hosts by blood-sucking insects. This protozoan is an obligate intracellular parasite. The infective forms of the parasite are metacyclic and bloodstream trypomastigote and amastigote. Metacyclic trypomastigotes are released with the fe...
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ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2016
ISSN: 1664-302X
DOI: 10.3389/fmicb.2016.00388